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Prof. SERGE LUQUET, Université Paris Cité
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Our scientific portfolio
Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice
Chronic stress constitutes a major risk factor for depression that can disrupt various aspects of homeostasis, including the gut microbiome (GM). Our research shows that vagotomy abrogates adult HPC neurogenesis deficits, neuroinflammation and depressive-like behavior, suggesting that vagal afferent pathways are necessary to drive GM-mediated effects on the brain.
Modeling of SARS-CoV-2 Virus Proteins: Implications on Its Proteome.
COronaVIrus Disease 19 (COVID-19) is a severe acute respiratory syndrome (SARS) caused by a group of beta coronaviruses, SARS-CoV-2. The SARS-CoV-2 virus is similar to previous SARS- and MERS-causing strains and has infected nearly six hundred and fifty million people all over the globe, while the death toll has crossed the six million mark (as of December, 2022). In this chapter, we look at how computational modeling approaches of the viral proteins could help us understand the various processes in the viral life cycle inside the host, an understanding of which might provide key insights in mitigating this and future threats. This understanding helps us identify key targets for the purpose of drug discovery and vaccine development.
SARS- CoV-2 viroporins:
A multi-omics insight from nucleotides to amino acids
The study of two prominent viroporins of SARS-CoV-2: Orf3a and (E) protein from a sequential and structural point of view.
Structural insight into the role of novel SARS-CoV-2 E protein: A potential target for vaccine development and other therapeutic strategies
Using the bioinformatics and structural modelling approach, we modelled the structure of the envelope (E)-protein of novel SARS-CoV-2, and propose that it plays a critical role in viral infection and pathogenesis.